Urinary Excretion of Metabolites of Trichloroethylene.
نویسندگان
چکیده
منابع مشابه
Differences in urinary trichloroethylene metabolites of animals.
Differences in urinary excretion of trichloroethylene were studied in rabbits, rats and mice. Trichloretylene (1 m mole/kg) was injected intra-peritoneally, then urinary trichloroacetic acid and trichloroethanol glucuronide were measured. The results were: 1. The ratio of total excretion of trichloroethylene metabolites to the administered trichloroethylene decreased in the order of mice, rats ...
متن کاملCardiac teratogenicity of trichloroethylene metabolites.
OBJECTIVES The hypothesis of this study was that metabolites of trichloroethylene (TCE), dichloroethylene (DCE) and related compounds were responsible for fetal cardiac teratogenic effects seen when TCE or DCE is consumed by pregnant rats during organogenesis. Identification of teratogenic metabolites would allow more accurate assessment of environmental contaminants and public health risks fro...
متن کاملPathological excretion patterns of urinary proteins in renal cell cancer patients exposed to trichloroethylene.
A study was carried out to investigate urinary protein excretion patterns by means of SDS-polyacrylamide-gel-electrophoresis (SDS-PAGE) in renal cell cancer patients who had previously been exposed to high levels of trichloroethylene. Thirty-eight out of 41 (93%) renal cell cancer patients investigated had former extensive trichloroethylene exposure, but only 23 out of 50 (46%) renal cell cance...
متن کاملMutagenicity of trichloroethylene and its metabolites: implications for the risk assessment of trichloroethylene.
This article addresses the evidence that trichloroethylene (TCE) or its metabolites might mediate tumor formation via a mutagenic mode of action. We review and draw conclusions from the published mutagenicity and genotoxicity information for TCE and its metabolites, chloral hydrate (CH), dichloroacetic acid (DCA), trichloroacetic acid (TCA), trichloroethanol, S-(1, 2-dichlorovinyl)-l-cysteine (...
متن کاملA review: trichloroethylene metabolites: potential cardiac teratogens.
This review is a a series of the authors' studies designed to test the hypothesis that administration of trichloroethylene (TCE), dichloroethylene (DCE), their metabolites, and related compounds are responsible for fetal cardiac teratogenesis when given to pregnant rats during organogenesis. Identification of teratogenic compounds will allow more accurate assessment of environmental contaminant...
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ژورنال
عنوان ژورنال: Sangyo Igaku
سال: 1959
ISSN: 0047-1879,1881-1302
DOI: 10.1539/joh1959.1.378